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| Registros recuperados: 215 | |
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| Cesar,Augusto; Abessa,Denis Moledo de Souza; Pereira,Camilo Dias Seabra; Santos,Aldo Ramos; Fernández,Nuria; Choueri,Rodrigo Brasil; DelValls,Tomas Angel. |
| In this work, multivariate and numeric methods were used to integrate the chemical and ecotoxicological data obtained for the sediments from the Santos Estuarine System, and for the vicinity of the discharges of the Submarine Sewage Outfall of Santos, in order to establish more accurately the environmental risks, identify the priority areas and thus provide guidance to control the programs and public policies. For both the datasets, the concentrations which exceeded numeric sediment guidelines tended to be associated to toxicity. For the estuary, this trend was corroborated by the correlations between the toxicity and Cu and PAHs levels, whereas for the sewage outfall region, this was observed through the correlation between the toxicity and Hg contents.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sediment; Contamination; Toxicity; Tiburonella viscana; Environmental risk assessment. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000100028 |
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| Lopes,Clarissa Elize; Langoski,Gisele; Klein,Traudi; Ferrari,Priscileila Colerato; Farago,Paulo Vitor. |
| ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and solid lipid nanoparticles, was developed and validated regarding the drug's encapsulation efficiency and in vitro permeation. The development and validation of the analytical method were carried out using the high performance liquid chromatography with the UV detection at 239 nm. The validation parameters were specificity, linearity, precision and accuracy, limits of detection and quantitation, and robustness. The method presented an isocratic flow rate of 1.0... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Halcinonide/encapsulation efficiency; Halcinonide/quantification; Polymeric lipid-core nanoparticles; Solid lipid nanoparticles; Topical administration; Toxicity; High performance liquid chromatography/method validation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200604 |
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| Santini,G.; De Souza,C.; Aversa,S.; Patti,C.; Tedeschi,L.; Candela,M.; Olivieri,A.; Chisesi,T.; Rubagotti,A.; Centurioni,R.; Nardi,V.; Congiu,M.; Gennaro,M.; Truini,M.. |
| The objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47 males and 46 females, median age 45 years) with aggressive localized non-Hodgkin's lymphoma, 43 in stage I and 50 in stage II (non-bulky), were included in the study. Stage I patients received VACOP-B for 6 weeks plus involved field radiotherapy and stage II patients received 12 weeks VACOP-B plus involved field radiotherapy on residual masses. Eighty-six (92.5%) achieved complete remission and 4 (4.3%) partial remission. Three patients (3.2%) were primarily... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Localized aggressive non-Hodgkin's lymphoma; VACOP-B; Radiotherapy; Toxicity. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500014 |
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| Camarillo de la Rosa, Gabriela. |
| Con la finalidad de proteger a los cultivos de las plagas sin provocar daño al ambiente y al humano, se ha generado la búsqueda de sustancias vegetales insecticidas y repelentes efectivos. El objetivo de este trabajo fue identificar los compuestos principales en el aceite esencial del anisillo Tagetes filifolia Lag. y evaluar la actividad biológica de extractos acuosos, aceites y turbios de flores, hojas, planta completa y raíz y el compuesto trans-anetol sobre la mosca blanca de los invernaderos Trialeurodes vaporariorum West. (Hemiptera: Aleyrodidae). Los compuestos se identificaron mediante cromatografía de gases acoplado a un espectrómetro de masas. Se evaluó repelencia al exponer adultos a un disco foliar tratado dentro de un cilindro por 24 h;... |
| Tipo: Tesis |
Palavras-chave: Aceites esenciales; Tagetes; Inhibición de oviposición; Mortalidad; Repelencia; Essentials oils; Tagetes; Oviposition inhibition; Toxicity; Repellency. |
| Ano: 2009 |
URL: http://hdl.handle.net/10521/1542 |
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| Camarillo de la Rosa, Gabriela. |
| Con la finalidad de proteger a los cultivos de las plagas sin provocar daño al ambiente y al humano, se ha generado la búsqueda de sustancias vegetales insecticidas y repelentes efectivos. El objetivo de este trabajo fue identificar los compuestos principales en el aceite esencial del anisillo Tagetes filifolia Lag. y evaluar la actividad biológica de extractos acuosos, aceites y turbios de flores, hojas, planta completa y raíz y el compuesto trans-anetol sobre la mosca blanca de los invernaderos Trialeurodes vaporariorum West. (Hemiptera: Aleyrodidae). Los compuestos se identificaron mediante cromatografía de gases acoplado a un espectrómetro de masas. Se evaluó repelencia al exponer adultos a un disco foliar tratado dentro de un cilindro por 24 h;... |
| Tipo: Tesis |
Palavras-chave: Aceites esenciales; Tagetes; Inhibición de oviposición; Mortalidad; Repelencia Essentials oils; Tagetes; Oviposition inhibition; Toxicity; Repellency. |
| Ano: 2012 |
URL: http://hdl.handle.net/10521/1039 |
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| Santos,Rudã F.B.; Dias,Henrique M.; Fujimoto,Rodrigo Y.. |
| The objective of this work was to evaluate the acute toxicity of formalin and histopathological effects on the Amazon ornamental fish, bluespotted coridora (Corydoras melanistius). A randomized design was used, with ten concentrations of formalin (40%) (0, 3, 6, 12, 25, 50, 100, 150, 200 and 250mg.L-1) with four replicates and five fish per container (3L) in static system for 96 hours. The moribund fish were killed and fixed in 10% formalin to proceed the histopathological analysis of gill, liver and kidney. At the end of this experiment the following mortality rates (%) were obtained in increasing order of exposure: 0, 0, 0, 0, 0, 65, 85, 100, 100 and 100%. The lethal concentration 50% (LC50-96h (I)) estimated was 50.76 mg.L-1 with regression of y =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lethal concentration; Corydora; Formaldehyde; Toxicity; Histology; Amazon. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400014 |
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| ManiRam,Prasad; Abhishek,Kumar; Diwakar,Mishra; Sunil K,Srivastav; Ajai K,Srivastav. |
| An acute toxicity test was performed by using a four-day static renewal test to determine the LC50 value of aqueous extract of Euphorbia royleana latex for the freshwater fsh, Heteropneustes fossilis. The LC50 values, their upper and lower confdence limits and slope functions were calculated. The LC50 values for aqueous extract of Euphorbia royleana latex at various exposure periods were 7.758 mg/L for 24 h, 5.847 mg/L for 48 h, 4.474 mg/L for 72 h and 3.090 mg/L for 96 h. The regression coeffcient showed that there was signifcant negative correlation between exposure time and different LC values. Hence, it is concluded that the concentration to produce toxicity of latex of Euphorbia royleana is comparable and close to the concentration to produce toxicity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fish; Euphorbia royleana; Toxicity; LC50. |
| Ano: 2010 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432010000100001 |
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| Kreutz,Luiz Carlos; Barcellos,Leonardo José Gil; Silva,Tális Oliveira; Anziliero,Deniz; Martins,Daiana; Lorenson,Monique; Marteninghe,Ariane; Silva,Leonardo Bolognese da. |
| Toxicity risks of agricultural pesticides to fishes are pivotal. Currently, many questions remain unsolved regarding to the toxicity of commonly used pesticides to silver catfish (Rhamdia quelen), a South American catfish. The present studies have been designed to investigate the acute toxicity and the lethal concentration (LC50) of four herbicides, two fungicides and two insecticides to silver catfish fingerlings. All experiments were carried out in triplicates, in a static bioassay system, using commercially available pesticides. The data was analyzed through the Trimmed Spearman-Karber method available from the Environmental Protection Agency. The 96hLC50 and 95% lower and upper confidence limits, respectively, for the following pesticides were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bioassay; Toxicity; Pesticides; LC50; Rhamdia quelen. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000400022 |
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| Humeres,Eduardo; Da Cruz,Ivana B.M.; Oliveira,Alice K. de. |
| Effect of age, sex and time exposure of Anastrepha fraterculus (Wied.) to toxicity of fenthion was evaluated. The age of the flies was important to the appearance of the first intoxication symptoms; males and females of reproductive ages (30 and 60 days-old, respectively) were less susceptible to insecticide than flies in the remainder ages (four and 120 days-old). The effect of body weight on insect intoxication was not detected. LT 50 biossay with fenthion (varying from 3-7 minutes) showed a lower susceptibility of males than females at all ages. Adults of both sexes and 30 days-old submitted to continuous and discontinuous exposure to fenthion did not show toxic cumulative effect of the insecticide. The statistical analysis suggests a possible general... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insecta; Fruit-fly; Insecticide; Toxicity. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591999000200011 |
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| Batista,Michelli Fernandes; Moscheta,Ismar Sebastião; Bonato,Carlos Moacir; Batista,Marcelo Augusto; Almeida,Odair José Garcia de; Inoue,Tadeu Takeyoshi. |
| Aluminum (Al) toxicity is one of the most limiting factors for productivity. This research was carried out to assess the influence of Al nutrient solution on plant height, dry weight and morphoanatomical alterations in corn (Zea mays L.) roots and leaves. The experiment was conducted in a greenhouse with five treatments consisting of Al doses (0, 25, 75, 150, and 300 µmol L-1) and six replications. The solutions were constantly aerated, and the pH was initially adjusted to 4.3. The shoot dry matter, root dry matter and plant height decreased significantly with increasing Al concentrations. Compared to the control plants, it was observed that the root growth of corn plants in Al solutions was inhibited, there were fewer lateral roots and the development of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dry matter production; Height; Toxicity; Zea mays L.. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-06832013000100018 |
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| CARVALHO,FRANCISCO R.S.; MOURA,ANTONIO G.; RODRIGUES,GARDENIA F.; NUNES,NARCIA M.F.; LIMA,DAISY J.B.; PESSOA,CLAUDIA; COSTA,MARCILIA P.; FERREIRA,PAULO M.P.; PERON,ANA PAULA. |
| ABSTRACT The objective of this study was to evaluate the antiproliferative, cytotoxic and genotoxic potential of salty liquid synthetic flavorings of Butter, Cheddar Cheese and Onion. The antiproliferative potential (2.9-1500 µg/mL) was assessed by MTT assay after 72h using the human tumor lines SF-295 (glioblastoma), OVCAR-8 (ovarian), HCT-116 (colon) and HL-60 (promyelocytic leukemia) and primary cultures of murine Sarcoma 180 (S180) and peripheral blood mononuclear cells (PBMC). Allium cepa bulbs were exposed to growing respective doses (1 mL and 2 mL). Only Butter and Cheddar flavorings revealed cytotoxic activity on cancer cells, with IC50 values ranging from 125.4 µg/mL (Cheddar - HCT-116) to 402.6 µg/mL (Butter - OVCAR-8). Butter flavoring was the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food additives; Allium cepa; Antiproliferative action; Neoplasic cells; Toxicity. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401419 |
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| Registros recuperados: 215 | |
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